Journal: Scientific Reports

Article Title: Comparison of extraocular and intraocular pressure transducers for measurement of transient intraocular pressure fluctuations using continuous wireless telemetry

doi: 10.1038/s41598-020-77880-8

Figure Lengend Snippet: (top) Model-based mean number of transient IOP fluctuations per hour for the sleep and wake periods by system with 95% confidence intervals (bottom) and model-based mean relative contribution of transient IOP fluctuations to total IOP for the sleep and wake periods by system with 95% confidence intervals.

Article Snippet: Figure 4 (Top) Konigsberg Extraocular (EO) System; ( A) Photograph of the second-generation Konigsberg Instruments T27G total implant system for continuous monitoring of bilateral IOP (extraocular), bilateral electrooculogram (EOG), aortic blood pressure, and body temperature. (B and C) A 23-gauge silicone tube delivers aqueous from the anterior chamber to a fluid reservoir on the intra-orbital side of the transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber, sutured to the sclera using the integral scleral anchor plate, and covered with a corneal patch graft (not shown). ( Adapted from Downs et a l. with permission.) (Middle) TSE-Stellar Extraocular (EO) System; ( D ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP extraocular total implant system; ( E ) A 23-gauge silicone tube delivers aqueous from the anterior chamber to an extra-orbital fluid reservoir containing a piezoelectric IOP transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber and sutured to the sclera using integral suture patches ( F ) En face photograph of the tube in the anterior chamber; ( G ) Slit lamp photograph of the intraocular placement of the tube in the anterior chamber relative to the cornea and iris. (Bottom) TSE-Stellar Intraocular (IO) System; ( H ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP intraocular total implant system; ( I) Top view of the IOP transducer and integrated scleral baseplate for affixing the transducer to the eye wall under Tenon’s capsule and conjunctiva; ( J ) Side view of the IOP transducer and integrated scleral baseplate; ( K ) En face photograph of the piezoelectric IOP transducer in the anterior chamber; ( L ) Slit lamp photograph of the intraocular placement of the piezoelectric IOP transducer in the anterior chamber relative to the cornea and iris. (Adapted from Jasien et al. with permission).

Techniques:

Journal: Scientific Reports

Article Title: Comparison of extraocular and intraocular pressure transducers for measurement of transient intraocular pressure fluctuations using continuous wireless telemetry

doi: 10.1038/s41598-020-77880-8

Figure Lengend Snippet: Boxplots comparing the frequency distributions of the mean number of transient IOP fluctuations per hour in each of the implant types (red, Konigsberg EO; blue, Stellar EO; green, Stellar IO) by NHP and eye in two magnitude bins (> 0.6 mmHg and > 15 mmHg above baseline IOP). (A) Average number of transient IOP fluctuations > 0.6 mmHg during the sleeping period for all animals (B) Average number of transient IOP fluctuations > 0.6 mmHg during the waking period for all animals (C) Average number of transient IOP fluctuations > 15 mmHg during the sleeping period for animals (D) Average number of transient IOP fluctuations > 15 mmHg during the waking period for all animals. The central thick line in the box represents the median number of peaks, the box extents represent the central 50% of the data, the bars represent the minimum and maximum, and the dots represent the outliers.

Article Snippet: Figure 4 (Top) Konigsberg Extraocular (EO) System; ( A) Photograph of the second-generation Konigsberg Instruments T27G total implant system for continuous monitoring of bilateral IOP (extraocular), bilateral electrooculogram (EOG), aortic blood pressure, and body temperature. (B and C) A 23-gauge silicone tube delivers aqueous from the anterior chamber to a fluid reservoir on the intra-orbital side of the transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber, sutured to the sclera using the integral scleral anchor plate, and covered with a corneal patch graft (not shown). ( Adapted from Downs et a l. with permission.) (Middle) TSE-Stellar Extraocular (EO) System; ( D ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP extraocular total implant system; ( E ) A 23-gauge silicone tube delivers aqueous from the anterior chamber to an extra-orbital fluid reservoir containing a piezoelectric IOP transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber and sutured to the sclera using integral suture patches ( F ) En face photograph of the tube in the anterior chamber; ( G ) Slit lamp photograph of the intraocular placement of the tube in the anterior chamber relative to the cornea and iris. (Bottom) TSE-Stellar Intraocular (IO) System; ( H ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP intraocular total implant system; ( I) Top view of the IOP transducer and integrated scleral baseplate for affixing the transducer to the eye wall under Tenon’s capsule and conjunctiva; ( J ) Side view of the IOP transducer and integrated scleral baseplate; ( K ) En face photograph of the piezoelectric IOP transducer in the anterior chamber; ( L ) Slit lamp photograph of the intraocular placement of the piezoelectric IOP transducer in the anterior chamber relative to the cornea and iris. (Adapted from Jasien et al. with permission).

Techniques:

Journal: Scientific Reports

Article Title: Comparison of extraocular and intraocular pressure transducers for measurement of transient intraocular pressure fluctuations using continuous wireless telemetry

doi: 10.1038/s41598-020-77880-8

Figure Lengend Snippet: Data comparison between the TSE-Stellar IO (left) and TSE-Stellar EO (middle) and Konigsberg EO (right , adapted from Turner et al. with permission ) transducers. (Top) The daily mean number of transient IOP fluctuations per hour over 0.6 mmHg in magnitude during waking hours (6AM-6PM) plotted over the entire data acquisition period in each eye. Each data point represents one day of data, presented as the mean number of transient IOP fluctuations per hour during the 12 waking hours. The eye must withstand ~ 10,000 transient IOP fluctuations every hour during waking hours. (Middle) The mean hourly frequency distribution of transient IOP fluctuation magnitude during waking hours for each eye binned by the magnitude for all data collected (error bars are standard deviation). (Bottom) Mean hourly IOP transient impulse, plotted as percentage of total IOP impulse, for all eyes of all animals. The plotted values are a measure of the amount of energy the eye must withstand from transient IOP fluctuations relative to the total IOP energy the eye must absorb. Waking hours are highlighted.

Article Snippet: Figure 4 (Top) Konigsberg Extraocular (EO) System; ( A) Photograph of the second-generation Konigsberg Instruments T27G total implant system for continuous monitoring of bilateral IOP (extraocular), bilateral electrooculogram (EOG), aortic blood pressure, and body temperature. (B and C) A 23-gauge silicone tube delivers aqueous from the anterior chamber to a fluid reservoir on the intra-orbital side of the transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber, sutured to the sclera using the integral scleral anchor plate, and covered with a corneal patch graft (not shown). ( Adapted from Downs et a l. with permission.) (Middle) TSE-Stellar Extraocular (EO) System; ( D ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP extraocular total implant system; ( E ) A 23-gauge silicone tube delivers aqueous from the anterior chamber to an extra-orbital fluid reservoir containing a piezoelectric IOP transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber and sutured to the sclera using integral suture patches ( F ) En face photograph of the tube in the anterior chamber; ( G ) Slit lamp photograph of the intraocular placement of the tube in the anterior chamber relative to the cornea and iris. (Bottom) TSE-Stellar Intraocular (IO) System; ( H ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP intraocular total implant system; ( I) Top view of the IOP transducer and integrated scleral baseplate for affixing the transducer to the eye wall under Tenon’s capsule and conjunctiva; ( J ) Side view of the IOP transducer and integrated scleral baseplate; ( K ) En face photograph of the piezoelectric IOP transducer in the anterior chamber; ( L ) Slit lamp photograph of the intraocular placement of the piezoelectric IOP transducer in the anterior chamber relative to the cornea and iris. (Adapted from Jasien et al. with permission).

Techniques: Standard Deviation

Journal: Scientific Reports

Article Title: Comparison of extraocular and intraocular pressure transducers for measurement of transient intraocular pressure fluctuations using continuous wireless telemetry

doi: 10.1038/s41598-020-77880-8

Figure Lengend Snippet: Animal demographics; separated by telemetry system and extraocular (EO) or intraocular (IO) transducer location and length of time (days) data were collected by system and transducer.

Article Snippet: Figure 4 (Top) Konigsberg Extraocular (EO) System; ( A) Photograph of the second-generation Konigsberg Instruments T27G total implant system for continuous monitoring of bilateral IOP (extraocular), bilateral electrooculogram (EOG), aortic blood pressure, and body temperature. (B and C) A 23-gauge silicone tube delivers aqueous from the anterior chamber to a fluid reservoir on the intra-orbital side of the transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber, sutured to the sclera using the integral scleral anchor plate, and covered with a corneal patch graft (not shown). ( Adapted from Downs et a l. with permission.) (Middle) TSE-Stellar Extraocular (EO) System; ( D ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP extraocular total implant system; ( E ) A 23-gauge silicone tube delivers aqueous from the anterior chamber to an extra-orbital fluid reservoir containing a piezoelectric IOP transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber and sutured to the sclera using integral suture patches ( F ) En face photograph of the tube in the anterior chamber; ( G ) Slit lamp photograph of the intraocular placement of the tube in the anterior chamber relative to the cornea and iris. (Bottom) TSE-Stellar Intraocular (IO) System; ( H ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP intraocular total implant system; ( I) Top view of the IOP transducer and integrated scleral baseplate for affixing the transducer to the eye wall under Tenon’s capsule and conjunctiva; ( J ) Side view of the IOP transducer and integrated scleral baseplate; ( K ) En face photograph of the piezoelectric IOP transducer in the anterior chamber; ( L ) Slit lamp photograph of the intraocular placement of the piezoelectric IOP transducer in the anterior chamber relative to the cornea and iris. (Adapted from Jasien et al. with permission).

Techniques:

Journal: Scientific Reports

Article Title: Comparison of extraocular and intraocular pressure transducers for measurement of transient intraocular pressure fluctuations using continuous wireless telemetry

doi: 10.1038/s41598-020-77880-8

Figure Lengend Snippet: (Top) Konigsberg Extraocular (EO) System; ( A) Photograph of the second-generation Konigsberg Instruments T27G total implant system for continuous monitoring of bilateral IOP (extraocular), bilateral electrooculogram (EOG), aortic blood pressure, and body temperature. (B and C) A 23-gauge silicone tube delivers aqueous from the anterior chamber to a fluid reservoir on the intra-orbital side of the transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber, sutured to the sclera using the integral scleral anchor plate, and covered with a corneal patch graft (not shown). ( Adapted from Downs et a l. with permission.) (Middle) TSE-Stellar Extraocular (EO) System; ( D ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP extraocular total implant system; ( E ) A 23-gauge silicone tube delivers aqueous from the anterior chamber to an extra-orbital fluid reservoir containing a piezoelectric IOP transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber and sutured to the sclera using integral suture patches ( F ) En face photograph of the tube in the anterior chamber; ( G ) Slit lamp photograph of the intraocular placement of the tube in the anterior chamber relative to the cornea and iris. (Bottom) TSE-Stellar Intraocular (IO) System; ( H ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP intraocular total implant system; ( I) Top view of the IOP transducer and integrated scleral baseplate for affixing the transducer to the eye wall under Tenon’s capsule and conjunctiva; ( J ) Side view of the IOP transducer and integrated scleral baseplate; ( K ) En face photograph of the piezoelectric IOP transducer in the anterior chamber; ( L ) Slit lamp photograph of the intraocular placement of the piezoelectric IOP transducer in the anterior chamber relative to the cornea and iris. (Adapted from Jasien et al. with permission).

Article Snippet: Figure 4 (Top) Konigsberg Extraocular (EO) System; ( A) Photograph of the second-generation Konigsberg Instruments T27G total implant system for continuous monitoring of bilateral IOP (extraocular), bilateral electrooculogram (EOG), aortic blood pressure, and body temperature. (B and C) A 23-gauge silicone tube delivers aqueous from the anterior chamber to a fluid reservoir on the intra-orbital side of the transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber, sutured to the sclera using the integral scleral anchor plate, and covered with a corneal patch graft (not shown). ( Adapted from Downs et a l. with permission.) (Middle) TSE-Stellar Extraocular (EO) System; ( D ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP extraocular total implant system; ( E ) A 23-gauge silicone tube delivers aqueous from the anterior chamber to an extra-orbital fluid reservoir containing a piezoelectric IOP transducer; the tube (with appropriate slack to allow for eye movement) is trimmed, inserted into the anterior chamber and sutured to the sclera using integral suture patches ( F ) En face photograph of the tube in the anterior chamber; ( G ) Slit lamp photograph of the intraocular placement of the tube in the anterior chamber relative to the cornea and iris. (Bottom) TSE-Stellar Intraocular (IO) System; ( H ) Photograph of the TSE-Systems Stellar Bilateral IOP/BP intraocular total implant system; ( I) Top view of the IOP transducer and integrated scleral baseplate for affixing the transducer to the eye wall under Tenon’s capsule and conjunctiva; ( J ) Side view of the IOP transducer and integrated scleral baseplate; ( K ) En face photograph of the piezoelectric IOP transducer in the anterior chamber; ( L ) Slit lamp photograph of the intraocular placement of the piezoelectric IOP transducer in the anterior chamber relative to the cornea and iris. (Adapted from Jasien et al. with permission).

Techniques: